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NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens: A Novel NMR-Tool for Natural Product Detection

By (author) Martin Lorenz Stein

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Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.

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Normally shipped | Available from overseas. Usually dispatched in 14 days
Publisher | Springer International Publishing AG
Published date | 17 Jul 2014
Language |
Format | Hardback
Pages | 71
Dimensions | 235 x 155 x 0mm (L x W x H)
Weight | 0g
ISBN | 978-3-3190-7913-4
Readership Age |
BISAC | science / life sciences / biochemistry

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Theory & Practice

Michelle de Kretser
Hardback
192 pages
was: R 422.95
now: R 380.95
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Broken Country: AMAZON'S BOOK OF THE YEAR - THE MILLION-COPY BESTSELLER

Clare Leslie Hall
Paperback / softback
320 pages

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An epic love story with the pulse of a thriller that asks: what would you risk for a second chance at first love?

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The Correspondent

Virginia Evans
Hardback
288 pages
was: R 450.95
now: R 405.95
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Exiles: Times book of the month 'Stanley Kubrick meets MR James'

Mason Coile
Paperback / softback
224 pages
was: R 520.95
now: R 468.95
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A terrifying locked-room mystery set in a remote outpost on Mars.

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